Immunosuppressant Durgs

1.

1 point

Photo-sensitivity is a potential side effect of immunosuppressants.

True

False

2.

1 point

Select the drug that is matched incorrectly.

Muromonab CD 3- transplant rejection once it has begun

Azathioprine - Rheumatoid Arthritis

Glatiramer Acetate - Rheumatoid Arthritis

Cyclosporine- prevention of transplant rejections

3.

1 point

Oral forms of the drug should be used whenever possible to avoid the risk for infection associated with IV administration.

True

False

4.

1 point

What is a concern and/or adverse effect of using immunosuppressant drugs

increased risk for opportunisitc infections

increased risk for severe hypertension

potential risk that the rejection will still occur

increased risk for neurotoxic events and tremors

5.

1 point

Glatiramer acetate is the only immunosuppressant currently indicated for...

Rheumatoid arthritis

Multiple Sclerosis

GI obstruction

prevention of organ rejection

6.

1 point

St John's wart reduces the therapeutic levels of which drug? ....leading to organ rejection (echinacea/cat's claw may have similar effects because they boost the immune system as well)

Basiliximab

Cyclosporine

Muromonab CD 3

sirolimus

7.

1 point

Sirolimus is an immunosuppressive drug, antifungal, and antitumor....it works by inhibiting the activation of which cell?

B-lymphocytes

leukocytes

T-lymphocytes

LAK cells

8.

1 point

Immunosuppressant drugs can be administered with vaccines.

True- this is safe as long as the vaccines are inactivated

False- the drugs can reduce the effectiveness of the vaccine

9.

1 point

Sirolimus and Tacrolimus have short-half lives, so toxicity is not really a concern.

True- because they leave the body so quickly, toxicity is rarely an issue

False- they actually have long half-lives increasing the potential for toxicity and cumulative effects

10.

1 point

The patient informs the doctor that grapefruit juice is part of his daily diet...he asks the doctor whether he can continue to eat/drink it while he is on Cyclosporines, the doctor says....

NO, it will prevent the drug from working and your heart will be rejected

yes, eat as much as you like...it is delicious and nutritious

well....you need not avoid it entirely, however, try and maintain a steady consumption

no, how about you replace it with apples

11.

1 point

Oral immunosuppressants should be taken with food to minimize GI upset.

True

False

12.

1 point

Which of the following is not an adverse effect of Azathioprine?

leukopenia

neurotoxicity

thrombocytopenia

hepatoxicity

13.

1 point

Basiliximab has a tendency to cause an allergic reaction known as....

hives

cytokine release syndrome

anaphylaxis

flushing

14.

1 point

Relative contraindications for the use of immunosuppressants include renal or hepatic failure, hypertension...and

coronary artery disease

pregnancy

concurrent radiation therapy

multiple sclerosis

15.

1 point

The nurse monitors for signs of cytokine release syndrome....these signs/symptoms would include...

fluid overload, pitting edema

severe diarrhea

fever, dyspnea, general malaise

renal dysfunction

16.

1 point

Which of the following is not an indication for the use of Tacrolimus?

kidney transplant

liver transplant

bone marrow transplant

heart transplant

17.

1 point

How is cyclosporine usually prepared?

diluted in water and injected IM

diluted in NS or 5% dextrose IV

given orally only

diluted in 50% dextrose and given IV

18.

1 point

Cyclosporine is the primary immunosuppressant used in the prevention of kidney, liver, heart, and bone marrow rejection.

True

False

19.

1 point

When Tacrolimus is administered the patient requires very close assessment for the first___________because of the chance that an anaphylactic reaction may occur.

hour

30 minutes

day

week

20.

1 point

Patients taking immunosuppressants should avoid...

large crowds, movie theatres, malls

their own bedroom

gardening

using cleaning fluids

21.

1 point

Prior to administering Azathioprine, in addition to assessing bleeding tendency, which labs should be done

WBC and Platelet counts

aPTT

RBC count

liver test

22.

1 point

Which is not an adverse effect of Muromonab CD 3

albuminuria

flu-like symptoms

edema

vomiting

23.

1 point

Which is a contraindication for Muromonab CD 3?

fluid overload

hypotension

lethargy

thrush

24.

1 point

Oral doses of tacrolimus should be given on an empty stomach.

True

False

25.

1 point

Grapefruit juice has what effect on the bioavailability of Cyclosporines?

increase 20-200%

decrease 10%

no effect

increase 10%

26.

1 point

Immunosuppressant are PRIMARILY indicated for ....

prevention of malignant tumor growth

prevention of systemic infection

prevention of organ rejection

hyperbilirubinemia

27.

1 point

Pregnant women should only be given immunosuppressants in clinically urgent situations.

True

False

28.

1 point

Glatiramer acetate used to treat MS, can only be administered orally.

True- only in oral form

False- only in injectable form

29.

1 point

To avoid cytokine release syndrome in patients taking Basiliximab or Daclizumab...the patients will often be premedicated with which drug?

corticosteroids

NSAIDs

antihistamines

Tacrolimus

30.

1 point

Azathioprine is used as an adjunct medication to prevent the rejection of kidney transplants....and

prevent rejection of heart transplants

treat psoriasis

ameliorate severe RA

prevent rejection of bone marrow transplants

31.

1 point

This drug is indicated for the treatment of organ rejection once rejection has begun.

Cyclosporine

Tacrolimus

Muromonab CD3

Azathioprine