Pharmacology 1

1.

1 point

Which statement about Arachidonic Acid is false

It acts as a 2nd messenger

It can be made by converting DAG using diacylglycerol lipase

It can be made by converting free phospholipids using phospholipase A2

Arachidonic acid is inflammatory

2.

1 point

Which of the following is false?

NMDA receptor allows the passage of Ca2+ when open

Ca2+ is used to activate Calmodulin

G-alpha-i, causes vasoconstriction by allowing the passage of Ca2+.

IP3 triggers the release of Ca2+ from the ER.

3.

1 point

hERG is:

A Voltage gated K+ channel

A inwardly rectifying channel

Blocking causes Torsades de Pointes

All of the above.

4.

1 point

Adenylyl Cyclase is activated by:

Forskolin

Ca2+- Calmodulin

G-alpha-s

All of the above

5.

1 point

Calmodulin:( More than one answer)

Binds 4 Calcium ions cooperatively

Activates CaM kinase II by phosphorylation

Can activate Adenylnyl cyclase

Binds to CaM Kinase II

6.

1 point

Which of the following series is correct.
1. PIP3 kinase
2. IRS-1
3. Glycogen production
4. PKB

4,3,1,2

1,2,3,4

2,1,4,3

3,2,1,4

7.

1 point

Guanylyl cyclase: ( More than one answer)

Exists as both membrane bound and cytoplasmic forms

Is activated by Nitric oxide radical produced by endothelial cells

Produces cGMP which can relax smooth muscle

Is a nuclear receptor

8.

1 point

Which is true (more than one answer):

NO radical has a half life of 5-10 seconds

NO Synthase has multiple forms depending on cell type its in

Protein Kinase A phosphorylates CREB(cAMP Responce Element Binding Protein)

Phosphorylation is irreversible process

9.

1 point

Which of the following are ligand gated ionic channels (More than one answer):

Alpha 1 receptor

Alpha 2 receptor

Gaba(a) receptor

NMDA (glutamate) receptor

10.

1 point

Which of the following works through G-alpha-q (More than one answer)

Alpha 1 receptor

Beta 1 Receptor

Muscarinic 1,3,5 receptors

Serotonin 5-HT2

11.

1 point

Epidermal Growth Factor Receptor ( More than one answer)

Is important in oncogenesis

Is a Tyrosine Kinase

Exists as a inactive monomer and a active dimer

CetuxiMAB inhibits its tyrosine kinase phosphorylation action

12.

1 point

Insulin Receptor:

Exists as two subunits

Insulin stimulates the autophosphorylation of the alpha subunit

Has two diverging downstream effects

IRS-1 works to phosphorylate the membrane bound Ras G protein

13.

1 point

PIP3 activates:

The release of Ca2+ from the ER

Protein Kinase C

Protein Kinase B

Phospholipase C

14.

1 point

Which association is incorrect

G-Alpha-q ~ PLC ~DAG + IP3~ PKC

G-Alpha-s ~ Adenylyl Cyclase ~ cAMP ~Protein Kinase A

G-Alpha-i ~ Adenylyl Cyclase

Insulin ~IRS-1 ~ Protein Kinase B ~RaS ~ MAP-kinase

15.

1 point

Janus Kinases(JAKs): (More than one answer)

Are associated with cytokine receptors

Autophosphorylate themselves and the protein they are associated with

Phoshoylate STATS (Signal Transducers and Activators of Transcription)

STATS regulate immune function and angiogenesis

16.

1 point

A ligand that is unable to produce the maximal efficacy is considered a:

Partial Agonist

Inverse Agonist

Consistuitive Agonist

Competitive Antagonist

17.

1 point

Which of the following is False:

Nicotinic Receptor= Na+ and K+ permeablity

M1,M3, M5 =G-alpha-s

M2,M4 = G-alpha-i

D1,D5=G-alpha-s

18.

1 point

Which of the following is false

Low dose Epinephrine activates Beta 1 and 2 receptors

Low dose Dopamine activates G-alpha-s causing vasodilation

High doses of Epinephrine activate alpha 1 receptors

High doses of Dopamine are used for parkinsons treatment

19.

1 point

Protein Kinase C requires which of the following to fully activate: (More than one answer)

DAG

Ca2+

Phosphoinositide-dependent-kinase 1(PDK1)

Autophosphorylation

20.

1 point

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