10@10 breast/thyroid

Age older than 60.

Nephrolithiasis

A substantial decline in renal function

Depression and fatigue

A substantial decline in bone mass

Carcinoma

A nonfunctioning adenoma

A thyroid cyst

A colloid nodule

An autonomous nodule

The majority of patients recur within five years of diagnosis

More than 70% of breast cancer recurrence involve distant metastases

Pulmonary metastases are the most common initial site of distant recurrence

The local recurrence rate following breast-conserving procedures varies from 10% to 40% whether or not radiation was used

Recurrent disease will be seen in at least 35% of node-negative patients undergoing appropriate primary breast therapy

Nulliparity

Oophorectomy before age 35

Use of oral contraceptives

High-fat, high-caloric diet

Post-menopausal use of conjugated estrogens

Prognosis is improved with estrogen or progesterone receptor positivity

Increased thymidine labeling index, a measure of the proportion of cells in the DNA synthetic phase (S-phase), is associated with improved survival

High tumor levels of cathepsin D are associated with an improved prognosis

Immunohistochemical demonstration of active angiogenesis correlates with increased metastatic potential and poor prognosis

all the above

Ductal carcinoma in situ (DCIS) is associated with a significant risk of development of invasive ductal carcinoma in the same quadrant of the same breast as the initial lesion

DCIS should not be treated with breast conservation therapy

Lobular carcinoma in situ (LCIS) is the most common form of non-invasive breast cancer

When LCIS is found, there is an up to 50% chance of lobular carcinoma in situ of the contralateral breast

About one-third of patients with biopsy-proven LCIS develop invasive cancer, always of the same breast

Mutations in the p53 tumor suppressor gene

A mutation in the short arm of chromosome 2

The presence of a BRCA 1 gene on chromosome 17

The presence of the BRCA 2 gene on chromosome 13

The presence of a BRCA 1 gene on chromosome 7

The total dose given to the breast is usually in the range of 2500 to 3000 cGy

Radiation to the axillary nodal bed is normally part of the procedure in most patients

Long-term complications of radiation therapy include rib fractures and arm edema

Breast edema and skin erythema usually resolves within a few weeks

None of the above

Ocular involvement

Symptomatic large goiter

women of childbearing age

Concomitant thyroid nodule

All of the above

Contraceptive pills and pregnancy increase the amount of thyroxin-binding globulin (TBG), and, consequently, the total T 4 level.

Intravenous pyleography can lower the rate of active iodine uptake by the thyroid

A triiodothyronine (T 3) suppression test that demonstrates nonsuppressibility of thyroid function is compatible with the diagnosis of Graves' disease, toxic adenoma, or functioning carcinoma.

An increased serum cholesterol level in a hypothyroid patient indicates a thyroid cause

Anticonvulsive medications and chronic debilitating illnesses decrease the amount of TBG and, consequently, the total T 4 level.