PCB4233 Exam 3 part 1

MHC diversity is due to which of the following:

During antibody recombination the RSS region next to the V region has 23 base pairs between the palindromic heptamer and the nonamer. Which of these will it likely recombine with?

C3 convertases are dissociated by all of the following EXCEPT:

Which assay, discussed in lecture, is used to assess the amount of cell death?

Which theories were eventually combined to explain antibody diversity?
I. Germ-line theory
II. One gene, one polypeptide theory
III. Selective theory
IV. Somatic-variation theory

Which of the following gene segments are not located in the lambda light chain?

Which of the following correctly lists, in order from the 5' to 3' end, the genes contained in a rearranged kappa light chain?

Which pathway needs antigen-antibody complex for initiation?

Which of the following is NOT a domain of MHCI?

The Lectin and Alternative pathways are different from the Classical pathway in that they,

Which of the following pairs are incorrectly matched?

Which of the following regulators of complement is used in the alternative pathway of complement but NOT in the classical or lectin pathway?

Which is not a soluble protein of the classical pathway of complement activation?

Which of the following is true regarding skin transplantation between inbred mouse strains?

In the Classical Pathway, which molecules are needed for activation?

A male and female giant panda are mated in captivity. The male panda has haplotype b/k. The female panda has haplotype a/d. The female gives birth to fraternal twins. Without testing the haplotypes of the twin pandas which of the following statements is the correct?

Somatic hypermutation in humans and mice is different from templated somatic mutation in chickens, cattle, and sheep in that:

Complement does not directly mediate which of the following?

The initiation of the classical pathway is antibody independent, while the alternative and lectin pathways are antibody dependent.

Where, in the endocytic pathway, do MHC II molecules bind to peptide fragments?

What is the extended notation for C5 convertase in the alternative pathway?

Which of the following regulatory proteins block the formation of C3 convertase by binding to C4b or C3b in the complement cascade?
i. Factor H
ii. C4bBP
iii. Decay Accelerating Factor
iv. Membrane-cofactor Protein (MCP)

Which of the following is NOT true of ALL three complement activation pathways?

Viruses have developed a number of different strategies for evasion of complement activity. Which are the strategies?

I. interference with the binding of complement to antibody-antigen complexes
II. Mimicry of mammalian complement regulators.
III. incorporation of cellular complement regulators
IV. They ONLY act as a cofactor for inhibitory factor I

C3bBb has a limited half-life. What binds to C3bBb to stabilize it?

Which of the following is NOT true of Class II MHC molecules?

N-addition occurs in the ______ and is mediated by _______.

The complement system plays a role in the opsonization of bacteria, activation of inflammation, clearance of immune complexes, as well as in cell lysis.

Which one of these is least likely to be a method of presentation of Ag by MHC?

Which of the following are types of Ig gene modifications:
I. VDJ recombination
II. Somatic Hypermutation
III. RAG1/RAG2
IV. Class-switching

Generation of Antibody response are dependent on which of the following factors?

What are the two exons for the hydrophobic transmembrane segment of a membrane-bound antibody?

MASP-1 and MASP-2 are structurally similar to C1r and C1s.

Correctly order the initial steps of the Alternative Pathway
I: Diffusion of Ba
II: Cleavage of Factor B into Ba and Bb by Factor D
III: Spontaneous generation of C3b
IV: Cleavage of C3
V: Binding of Factor B stabilized by Mg+

In terms of the complement cascade, deficiency of which of the following regulatory proteins would result in disruption of ALL three complement pathways (classical, alternative, and lectin)?

Binding of _____ stabilizes C3 convertase in the alternative pathway.

Which of the following statements is false?

Which of the following is not a location of a one or two turn Recombination Signal Sequence (RSS)?

Which of the following statements is false?

How many coding regions does a functional lambda variable region gene have?

The Decay-accelerating factor binds and cleaves which of the following complex?

Which regulatory protein affects the alternative pathway only?

Like macrophages and dendritic cells, most APCs are phagocytic and internalize antigens primarily through phagocytosis.

What signals the recombination process that rearranges the heavy and light chain genes V-(D)-J?

What is the only human CH segment that does not have an upstream switch region?

The membrane attack complex (MAC) consists of C5b through C9, what triggers the initial exposure of the hydrophobic regions of the cell?

Which of the following gene rearrangement orders account for allelic exclusion:

A new peptide that scientists want to isolate is made up of 15 amino acids. In the central core, it has an internal conserved sequence motif but lacks conserved anchor residues. It has a proline residue at position 2 and another cluster of prolines at the carboxyl-terminal end. What might scientists find this protein attached to?

What determines-or helps ensure- proper segment order joining of these segments, ex.) V with J?

Which protein binds soluble C5b67 and prevents its insertion into the cell membrane?