Pharmacology 2

1.

1 point

Which two drugs are benzodiazepines?

Alprazolam

Phentobarbital

Diazepam

Ethanol

2.

1 point

Which of the following are consequences of using a vasoconstrictor such as adrenaline to counteract an aesthetic-induced vasodilation?

Decreased risk of bleeding from surgical manipulation

Prolongation of anesthetic action

Increased risk of toxicity

All of these

3.

1 point

What are the four main subtypes of GABAa receptors?

Alpha, kappa, gamma, delta,

alpha, beta, delta, phi

alpha, beta, gamma, delta

Delta, zeta, sigma, nu

4.

1 point

Which anti-psychotic has unique structure with partial agonist activity on the D2 receptor?

Olanzapine

Clozapine

Quetiapine

Aripiprazole

5.

1 point

Which of the following drugs is a partial agonist and a weak inhibitor of serotonin uptake?

Escitalopram

Bupropion

Alprazolam

Trazodone

6.

1 point

Which anticonvulsant inhibits succinate semialdehyde dehydrogenase and GABA transaminase? It also causes spina bifida and may be hepatotoxic.

Phenobarbital

Valproate

Ethosuximide

Phenytoin

7.

1 point

Which anticonvulsant prolongs the opening of the GABA-gated chloride channels?

Primidone

Valproate

Phenobarbital

Phenytoin

8.

1 point

Which three drugs are non-benzodiazepines that still work on its receptor?

Eszopiclone

Flurazepam

Zolpidem

Zaleplon

9.

1 point

Which two SSRI antidepressants have active metabolites?

Paorextine

Norfluoxetine

Fluoxetine

Fluvoxamine

10.

1 point

Which anticonvulsant causes the depolarization of a cell and allows sodium to flow in bringing it to equilibrium?

Valproate

Phenobarbital

Phenytoin

11.

1 point

Serotonin syndrome is due the excessive activation of the 5-HT2a receptors.

True

False

12.

1 point

Anesthesia Stages:
__ Disinhibiton
__ Analgesia
__ Surgical Analgesia
__ Medullary depression

IV, II, I, III

I, III, II, IV

II, I, III, IV

I, II, III, IV

13.

1 point

TCA's block Norepinephrine and serotonin transport.

True

False

14.

1 point

Local anesthetics block....

Voltage gated chloride channels

Sensory of transmission to brain from a localized area

Serotonin levels

Voltage-gated sodium channels

15.

1 point

Which anti-psychotic drug has a black box warning for agranulocytosis and requires frequent blood tests?

Olanzapine

Clozapine

Ziprasidone

Risperidone

16.

1 point

Which antidepressant has the worst side effect profile including the highest rates of sexual dysfunction?

Celexa

Paroxetine

Lexapro

Prozac

17.

1 point

Which anticonvulsant is contraindicated if a preexisting mental illness is present and is also an irreversible inhibitor of GABA transaminase?

Phenytoin

Vigabatrin

Phenobarbital

Lorazepam

18.

1 point

Select the following indication(s) for anti-psychotic drugs:

Parkinson's disease

Huntington's disease

Tourett's syndrome

Bipolar disorder

Nausea

Psychosis

19.

1 point

There is an indirect correlation between lipid solubility and potent.

True

False

20.

1 point

A simple partial seizure has a sudden change of consciousness.

True

False

21.

1 point

1. The most potent for serotonergic re-uptake blockade
2. Most selective SSRI
3. Most potent dopamine reuptake blockade
4. Most potent anti-cholinergic effect

These all have equal potency and selectivity.

Paroxetine, escitaplopram, sertraline, paroxetine

Escitalopram, paroxetine, sertraline, paroxetine

Paroxetine, sertraline, paroxetine, escitalopram

Escitalopram, sertaline, paroxetine, paroxetine

22.

1 point

The lower the blood to gas solubility coefficient, the faster the onset and termination of anesthesia.

True

False

23.

1 point

Balanced anesthesia can be exemplified by the following combination:

isoflurane + carbon doixide

Nitrous oxide + NSAID

tryptophan + nitrous oxide

Nitrous oxide + isoflurane

24.

1 point

Select all of the intravenous anesthetics below

Labetilol

Propofol

Thiopental

Droperidol

25.

1 point

There is a significant correlation between D2 receptor affinity and dosage.

True

False

26.

1 point

Which two drugs have the highest risk of weight gain and diabetes due to a worsening lipid profile? Hint: they also have the highest "30-day cost".

Quetiapine

Aripiprazole

Clozapine

Olanzapine

27.

1 point

Which of the following are effects of anti-psychotic drugs? (select all that apply)

Lowering of seizure threshold

Decrease hallucinations and delusions

Anti-emetic effect

Decreased prolactin release

Increasing temperature regulation

28.

1 point

What is the primary determinant of anesthetic potency?

Lipid solubility

Water insolubility

Lipid metabolism

Water solubility

29.

1 point

Which drug is used to treat manic-depressive, bipolar, illness?

Prozac

Lithium

Hydronium

Gentamycin

30.

1 point

Which drug is the most selective D2 receptor antagonist?

Paliperidone

Ibperidone

Chlopromazine

Haloperidol

31.

1 point

TCA effects include

Antimuscarinic effects

Alpha-adrenergic blockade

Sedation

Biploar disorder

Anti-emetic effects

Relieve depression by elevating mood

32.

1 point

Nitrous oxide is an example of an intravenous anesthetic.

True

False

33.

1 point

The interaction between MAO inhibitors and SSRIs is pharmacokinetic.

True

False

34.

1 point

Select which of the following are SSRI's

Fluoxetine

Fluvoxamine

Citalopram

Amitryptiline

Doxepin

Setraline

Paroxetine

Clomipramine

35.

1 point

Inhalation anesthetics:

Augment GABAa receptor function

Activate potassium channels

Increase cellular threshold for firing and decreasing neuronal activity

Block sodium channels

36.

1 point

A high D2/5-HT2a receptor ratio indicates low extra-pyramidal toxicity.

True

False

37.

1 point

Order of sensory function blockade:
Note: the recovery is in the reverse order!

Pain, cold, warmth, touch, deep pressure, motor

Deep pressure, pain, warmth, touch, motor

Pain, warmth, cold, deep pressure, touch, motor

Cold, warmth, touch, deep pressure, motor, pain

38.

1 point

What is the active ingredient in herbal antidepressant St. John's Wort?

Hyperforin

Hyperfurantoin

Benzodiazepene

Capsacin

39.

1 point

Which two drugs are primary treatment for status epilepticus?

Diazepam

Alprazolam

Phenobarbital

Lorazepam

40.

1 point

Which anticonvulsant is the drug of choice for absence seizures?

Xanax

Phenobarbital

Ethosuximide

Phenytoin

41.

1 point

Spasms of the tongue muscles treated by anti-parkinsonian agents are called

Bradykinesia

Akathisia

Dyskiniesia

Acute Dystonia

42.

1 point

Allergic reactions a more common with

Esters (Cocaine, procaine, tetracaine, benzocaine)

Amides (lidocaine, mepivacaine, carbocaine)

Topical administration

Epidurals

43.

1 point

Binding of GABA causes the channel to open and __1___ flow into the cell causing __2____

Potassium, hyperpolarization

Sodium, repolarization

Chloride, hyperpolarization

Chloride, depolarization

44.

1 point

Which of the following are typical (1st generation) Anti psychotics? (select all that apply)

Haloperidol

Quetiapine

Chlorpromazine

Clozapine

45.

1 point

Select which of the following are TCA's

Amitryptiline

Imipramine

Clomipramine

Doxepin

All of the above

46.

1 point

Fenofibrate is first line medication for seizures.

True

False

47.

1 point

Depression is the result of reduced levels of ______ _______ in the CNS.

Adrenergic amines

Biogenic amines

ATP synthase

THC elements

48.

1 point

Patients with forms of epilepsy usually exemplify ion channel dysfunction with rapid inactivation or reactivation.

True

False

49.

1 point

1st generation anti-psychotic drugs have affinity for 5-HT2a receptors while 2nd generations have an affinity for D2 receptors.

True

False

50.

1 point

A local anesthetic is normally completely irreversible and general anesthetics induce sleep.

True

False