exam2b

Of the following heavy chain constant region isotypes, which have subclasses?

Haptenes and their carrier proteins can yield AB specific responses to

Which of the following is TRUE about studies with immunogenicity and haptens?

All of the following are true regarding the chain composition of immunoglobulin classes EXCEPT which of the following?

An individual is unable to resolve inflammation due to abnormally low phagocytosis of apoptotic neutrophils. This is most likely caused by:

The hinge region is a peptide sequence located between the CH1 and CH2 domains that predominantly contains which amino acid?

The hinge region is a peptide sequence located between the CH1 and CH2 domains that predominantly contains which amino acid?

Which of the following cell types does NOT generate chemokines in the inflammatory response?

What is recognized by the Lectin Pathway for complement?

Which of the following is FALSE regarding B cells?

(see table 4-2 on slide 34 in lecture 3 ppt)

Which of the following responses would you NOT expect to see in tissue undergoing inflammation?

(Ch.5 slide 15)

Which of the following is FALSE?

The information can be found on slide 17 of the chapter 4 lecture

All of the following are true about B and T cell receptors except:

IgG from a rabbit is exposed to papain, which digests it into Fab and Fc fragments. These fragments are used to immunize a goat, which produces anti-Fab and anti-Fc antibodies in response. If this goat is now innoculated with heavy (H) chain fragments and light (L) chain fragments of the rabbit's IgG, to which antigens will each antibody bind?

Kuby 7th Pg 83

Which of the following is false regarding the difference between membrane bound and secreted forms of Immunoglobulins?

(found on page 90)

Which of the following cytokines are only secreted by NK cells?

Which of the following responses is FALSE regarding antibodies?

Chapter 3 lecture, slides 28 and 29.

Septic shock, caused by LPS from gram (+) bacteria, kills 20,000 people per year through decreased blood pressure and blood flow.

The complement system is formed by a group of proteins synthesized mostly in

Much of our initial knowledge of MHC came from experimentation with________

What are the best two major functions of antibody molecules?

Which of the following amino acids is typically involved in initiating enzymatic events while phosphorylated?

Which of the following is not part of secreted IgA uptake into the lumen?

What do antibodies recognize?

Which of the following is a Toll Like Receptor least likely to directly stimulate during a bacterial infection?

From the "Toll Like Receptor" slide in the "Receptor and Cytokines" lecture.

Which of the following is not true about haptens?

Which TLR has ligands such as GPI-linked proteins, peptidoglycans, zymosan and lipoproteins?

Which of the following is not true of C-reactive proteins?

Lecture chp 5 slide 29

Which of the following is true about reactive oxygen species (ROS)?

Which of the following results in an increase in affinity and more effective immune response?

lower Kd lecture on Chapter 3

Which immunoglobulin is the most abundant isotype in terms of serum concentration?

All of the following are involved in the production of Acute Phase Response Proteins(APRPs) except:

Although the Classical, Alternative, and Lectin pathway all begin differently, they all eventually make ____.

slide 6 of complement powerpoint

True or False:

The Tumor Necrosis Family (TNF) of cytokines is responsible for regulating development, homeostasis, and effector function of cells in the immune system only.

Pg123

The generation of antibody responses is NOT dependent on which of the following:


Answer: D

Different species inherit different constant-region genes and therefore express different ______.

Which adapter protein domain binds phosphorylated tyrosine (pY) residues?

Kuby Immunology pg 74

All of the following are proinflammatory cytokines except:

Which of the following is not an accessory molecule for signal transduciton in B cells?

Which of the following processes applied to an antibody will result in a complete loss of antigen binding activity:

Which of the following immunoglobulin proteins is most associated with the Digestive Tract?

Reference: slides 42-49 from Chapter 4

Which cytokine from the IL-1 family are processed by the enzyme caspase-1 in vitro?

Which of the following enzymes are not used as part of the host's defense?

Which Toll like receptors have an internal complement?

True or False:
The Tumor Necrosis Family (TNF) of cytokines is responsible for regulating development, homeostasis, and effector function of cells in the immune system only.

Which of the following is not part of the Lectin Pathway?

All of the following are true expect

Which one of these Ka or Kd values indicates the strongest antibody-receptor binding?

Which of the following is NOT an example of one of the molecular changes that may occur to the receptor upon receptor-ligand binding?

Which of the following is false regarding IgG:

I. Most abundant isotype in serum

II. Activates complement

III. Four human subtypes: IgG1, IgG2, IgG3, IgG4

IV. Subtypes vary in the size of hinge regions

V. All subtypes have the same number of disulfide bonds

a) b) c) d) e)

Ch. 3 Slide 61)