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Therapeutics exam 5

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1.
1 point
Which indicates a level of hepatic venous pressure that is higher than normal and would draw concern?
2.
1 point
Which measured value of portal vein pressure (hepatic venous pressure gradient) would indicated a high risk of variceal bleeding?
3.
1 point
Which measured value of portal vein pressure (hepatic venous pressure gradient) would indicated a high risk of spontaneous bacterial peritonitis?
4.
1 point
Which clinical manifestation of cirrhosis is the most common?
5.
1 point
Which of the following are hallmark lab parameters for cirrhosis?
6.
1 point
Thrombocytopenia is one of the highest predicted values for diagnosing cirrhosis. What value would indicate thrombocytopenia?
7.
1 point
Which of the following would you need to determine a Child-Pugh classification for severity of liver dysfunction?
8.
1 point
Which of the following lab values would indicate hepatic enchephalopathy due to liver failure if the patient has impaired cognitive function and poor motor abilities?
9.
1 point
To treat HE, we focus on the ammonia hypothesis. Which type of protein diet would be best to decrease the amount of ammonia?
10.
1 point
Which of the following is the main therapeutic agent for treatment of hepatic encephalopathy?
11.
1 point
Antibiotics are often considered in the treatment of HE as add-on therapy to lactulose.
Which of the following is the most common antibiotic therapy and dosing?
12.
1 point
Metronidazole, Neomycin and Vancomycin are alternative treatments for HE. Which one can have a disulfiram effect if the patient is still drinking alcohol?
13.
1 point
Which is a protective agent against ammonia causing HE?
14.
1 point
Which agent would be most helpful to treat HE for patients also receiving benzodiazepines?
15.
1 point
Which of the following could be complications of Ascites?
16.
1 point
NSAIDs, ACEI/ARBs, and propranolol can all decrease renal perfusion and need to be DC'd in ascites treatment.
17.
1 point
Which of the following medications should be used first line for treatment of ascites (complication of portal hypertension)? Also what is the dosage ratio?
18.
1 point
Which of the following would be reasons to DC treatment for ascites?
19.
1 point
Sometimes paracentesis may be necessary to remove large fluid volumes if the patient has tense ascites.
If more than 5 Liters are removed, what should be administered subsequently?
20.
1 point
What are two requirements for treatment of spontaneous bacterial peritonitis with antibiotics?
21.
1 point
Which organisms can cause a complication of portal hypertension called spontaneous bacterial peritonitis?
22.
1 point
Which of the following antibiotics are recommended for the treatment of SBP (spontaneous bacterial peritonitis)?
23.
1 point
Which medication would be best for the prevention of variceal bleeding?
24.
1 point
If a patient with portal hypertension presents to the hospital with variceal bleeding, which treatment would be most appropriate to try first?
25.
1 point
If a patient was treated for variceal bleeding, what secondary prevention medications could be considered?
26.
1 point
A TIPS procedure to connect the hepatic vein to the portal vein with a stent is only done in patients that have a high chance of liver transplant soon.
27.
1 point
Hepatorenal syndrome is a severe complication of cirrhosis. In decompensated cirrhosis, the blood pressure drops and can't be overcome by increasing HR, which is why you see so much renin produced.
Which of the following medications would be useful to increase blood pressure?
28.
1 point
When treating hepatorenal syndrome, we raise mean arterial pressure in hope that the Scr value will return to . . .
29.
1 point
Drug-induced liver injury is the most common cause of a drug being withdrawn from the market.
30.
1 point
Which part of our immunity is capable of producing both inflammatory (TNF-alpha, interferon) and hepatoprotective cytokines (prostaglandins) and interleukins?
31.
1 point
A direct cell damage (often dose related) usually due to toxic metabolites such as APAP and street drugs.
32.
1 point
Accumulation of fatty acids or phospholipids in hepatocytes result in steatohepatitis and phospholipidosis.
Which drug is an example of phospholipidosis?
33.
1 point
Accumulation of fatty acids or phospholipids in hepatocytes results in steatohepatitis and phospholipidosis.
Which drug(s) is responsible for steatohepatitis?
34.
1 point
Lesions forming in hepatic venules, sinusoids or the portal vein due to androgens, estrogens, tamoxifen or azathioprine.
35.
1 point
Isoniazid hepatocellular injury is an example of . . .
36.
1 point
Methotrexate and high-dose vitamin A eventually cause fibrosis of the liver.
This is an example of. . .
37.
1 point
Chlorpromazine, augmentin, and carbamazepine prevent movement of bile (containing toxic excretion products) from the liver into the gallbladder for excretion. This is an example of . . .
38.
1 point
Drugs with strong warning of hepatotoxicity include all of the following EXCEPT. . .
39.
1 point
Drugs with strong warning of hepatotoxicity include all of the following EXCEPT. .
40.
1 point
Which of the following hepatic viruses only develops in patients already infected with hepatitis B?
41.
1 point
Which virus is transmitted via fecal-oral, person-person and contaminated food or water?
42.
1 point
Which hepatitis virus are transmitted sexually, parenterally and perinatally?
43.
1 point
Which antigen of hepatitis B is the most abundant and produced in response to vaccination?
44.
1 point
The presence of the Anti-HBcAg antigen indicates . . .
45.
1 point
The incubation period of hepatitis B virus is asymptomatic or flu-like?
46.
1 point
The patient is experiencing diarrhea and has ascites, pale stools, cola colored urine and jaundice upon examination.
Would these S/S be indicative of acute or chronic viral hepatitis infection?
47.
1 point
Which HBV antibody appears at the onset of symptoms and persists for life?
48.
1 point
Positive Anti-HBs and negative HBsAg indicates protective immunity conferred by vaccine.
49.
1 point
Which treatment could be given SQ for chronic hepatitis B without decompensated cirrhosis?
50.
1 point
Dracula's lab values indicate an ALT of 150. Which of the following medications for chronic hepatitis B would be preferred?
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