Immuno 1.2

1.

1 point

Antibodies are the main killers of extracellular pathogens.

True

False

2.

1 point

An injection of which of the following immunoglobulins would be most likely to give you diarrhea?

IgM

IgG

IgD

IgE

IgA

3.

1 point

Alpha/beta T cell receptors are much more common than gamma/delta T cell receptors due to most developing T cells not having the gene for the gamma/delta version.

True

False

4.

1 point

Which of the following receptors would be LEAST likely to be found in the c-SMAC region of the T cell/Dendritic cell interaction?

MHC II

B7

CD8

LFA-1

5.

1 point

Neutrophils would most likely be summoned by the present of which CD4 T cell?

Th17

Th2

Tfh

Th1

6.

1 point

Presence of which of the following is NOT needed for Th1 cell differentiation?

IFN(gamma)

STAT4

T-bet

GATA3

IL-12

7.

1 point

Loss of which of the following would greatly decrease T cell activation?

CD45RO

CD45RA

S1P

L-selectin

8.

1 point

Which of the following is NOT required for antibody dependent cellular cytotoxicitiy?

CD8 T cells

Fc(gamma)RIII

NK cells

IgG

9.

1 point

If no CD4/8 receptor is present on an activating T cell, which of the following factors will not be bound and therefore, not able to begin a signaling cascade to turn on specific transcription factors.

ZAP70

CD28

Lck

CD3

10.

1 point

Which of the following cells are not directly involved in the immune response but help remove large immune complexes?

lymphocytes

macrophages

RBCs

neutrophils

endothelial cells

11.

1 point

Which of the following is NOT a way that a CD8 T cell can be activated?

multiple CD8 T cells bind to DC at the same time

highly activated DC makes large amounts of IL-2 and bound Ag

stimulation of DC by CD4 cell just prior to CD8 T cell binding

DC binds both a CD4 and CD8 T cell

12.

1 point

Which of the following would NOT suppress effector T cells?

IL-10

IL-21

TGF(beta)

Tregs

13.

1 point

Activation of a dendritic cell after exposure to a pathogen would result in all of the following EXCEPT...

increased expression of B7 on dendritic cell

migration to draining lymph node

release of chemokines to attract naive T cells

upregulation of dendritic cell CD28

14.

1 point

How does IgG get in to the tissue from circulation.

It is unable to move outside serum

It bind to E-selectin for transcytosis

It binds to the Brambell receptor on endothlial cells

It activates MAPK causing vasodilation

15.

1 point

Interaction between which two of the following receptors is strongest between an activating T cell and dendritic cell?

ICAM1

CD58 (LFA-3)

ICAM3

LFA1

CD2

16.

1 point

Which of the following locations is NOT an immune privileged site?

testes

liver

brain

eyes

fetus

17.

1 point

Which of the following is NOT a location that activated B cells will migrate to

bone marrow

germinal center

site of infection

lymph node

18.

1 point

In which of the following locations does T cell activation occur?

lymph node

thymus

bone marrow

site of infection

19.

1 point

If a patient is reinfected with a pathogen years later but does not mount a more efficient immune response, they may have a mutation in which of the following transcription factors?

GATA-3

STAT4

Bcl-6

MEK

Tbet

20.

1 point

What is the main reason why pathogenic infections sometimes lead to autoimmunity?

pathogenic damage to cells causes APCs to present self antigens along with pathogenic antigens

DAMPs are commonly associated with autoimmunity

more immune cells are activated during an infection

pathogens infect immune cells causing them to attack self tissue

21.

1 point

As opposed to B cells, T cell do not produce memory T cells at the end of infection.

True

False

22.

1 point

Which of the following is a legitimate definition of original antigenic sin?

antibody class switching depending on the type of infection

a secondary response occur quicker due to memory cells

eating the apple in the garden of eden

subsequent exposure to the same antigen activate memory cells and inhibit naive cells

23.

1 point

Which of the following is not a type of CD4 T cells?

Th2

Tfh

Th1

Th3

Th17

24.

1 point

Which of the following associate with T cell receptors in order to help with signal transduction?

CD28

CD33

CD3

CD40

25.

1 point

Which of the following is NOT characteristic of CD8 T cells?

release IFN(gamma)

used to help combat intracellular pathogens

releases lytic granules to cause necrosis of all proximal tissue

uses the Fas ligand cascade to release caspases

26.

1 point

Autoimmune lymphoprolipherative syndrome (ALPS) is caused by which of the following?

mutation of LFA-1

immune response against Rh+ blood

trauma to the eye allowing the immune system to bypass failsafes

mutation of Fas gene

27.

1 point

Loss of which of the following receptors would result in an effector T cell being forced back into lymph circulation even though it is not done being activated?

B7

S1P receptor

ICAM-1

MHC II

28.

1 point

Which of the following is associated with T cells but NOT B cells?

binding of free antigen

one antigen binding site

V, D and J regions

somatic hypermutation

no secreted form

29.

1 point

Which of the following transcription factors would NOT need to be activated for T cell differentiation?

NK-(kappa)B

NFAT

AP-1

SMAT

30.

1 point

Pneumococcal polysaccharides and LPS can activate B cells with just one signal.

True

False

31.

1 point

Which of the following antibodies would be LEAST likely to be found free in blood serum?

IgM

IgE

IgD

IgG

32.

1 point

Which of the following would result apoptosis of a B cell?

immature B cell not finding its antigen

mature B cell binding antigen but not a T cell

decreased amount of antigen present for an activated B cell

switching of isotype from IgM to IgG

33.

1 point

Which of the following effector T cells would be least likely to interact with macrophages?

Th17

Th2

Th1

CD8 T cells