Energy Rich Molecules and Glycolysis

1.

1 point

Which of the following equations WON’T equal ΔG?

-RT2lnKeq

Gproducts – Greactants

Δenthalpy – TΔentropy

ΔGo + RTln [C]^c x [D]^d / [A]^a x [B]^b, where all concentrations are at their initial concentrations.

2.

1 point

What happens when ΔG = 0?

Both the forward and backward reactions have stopped altogether.

The reaction is proceeding forward overall.

ΔG = ΔGo + RTln [C]^ci x [D]^di / [A]^ai x [B]^bi can be rearranged to ΔGo= -RTlnKeq, allowing us to find the standard free energy change.

The reaction is proceeding backward overall.

3.

1 point

The first reaction is unfavourable, but we can make it proceed forward if we couple it to the second reaction.

Glucose + Pi > G 6-P + H2O ΔG1’=13.8 kJ/mol
ATP + H2O > ADP + Pi ΔG2’ = -30.5 kJ/mol

By cancelling out H2O and Pi on both sides, we are left with the equation
Glucose + ATP > G 6-P + ADP.

What is the ΔG of this reaction?

+16.7 kJ/mol

-16.7 kJ/mol

+43.8 kJ/mol

-43.8 kJ/mol

4.

1 point

Which of the following is NOT true regarding glucose?

The most common form of glucose in the human body is in open chain form, and a minority is found in the alpha-D-glucopyranose and beta-D-glucopyranose forms.

C1 is an anomeric carbon.

The CHO group at C1 and OH group at C5 react together to form a hemiacetal linkage.

It is taken up by GLUT transporters.

5.

1 point

Which transporter is specifically found in the brain and neurons?

GLUT4

GLUT2

GLUT3

GLUT1

6.

1 point

How much ATP is produced during the preparatory phase of glycolysis?

-1

+1

-2

+2

7.

1 point

What is the first irreversible reaction of glycolysis?

Reaction 2: Isomerization of G-6-P

Reaction 4: Conversion and cleavage of F-1,6-bisP.

Reaction 1: Phosphorylation of glucose.

Reaction 3: Conversion of F-6-P

8.

1 point

Reaction 1 of glycolysis is catalyzed by:

Hexokinase in most tissues, and glucokinase in the liver.

Glucokinase in all tissues.

Hexokinase in all tissues.

Phosphohexose isomerase.

9.

1 point

Reaction 2 of glycolysis is the isomerization of glucose-6-phosphate to fructose-6-phosphate. It is catalyzed by:

Phosphofructosekinase-1

Triose phosphate isomerase

Phosphohexose isomerase

Aldolase

10.

1 point

Which reaction is both the first committed step of glycolysis and the rate-limiting step?

Reaction 1: Phosphorylation of glucose

Reaction 3: Conversion of fructose-6-phosphate to fructose-1,6-bisphosphate

Reaction 2: Isomerisation of glucose-6-phosphate to fructose-6-phosphate

Reaction 4: Conversion and cleavage of fructose-1,6-bisphosphate.

11.

1 point

Reaction 3 of glycolysis converts fructose-6-phosphate to fructose-1,6-biphosphate. Which enzyme catalyzes this?

Triose phosphate isomerase

Aldolase

Phosphofructosekinase-1

Hexokinase

12.

1 point

Reaction 4 of glycolysis involves aldolase cleaving fructose 1,6-bisphosphate in the middle to produce two compounds. What are these two compounds?

Dihydroxyacetone phosphate (DHAP) and nicotinamide adenine dinucleotide (NADH).

Glyceraldehyde-3-phosphate and 1,3-bisphosphoglycerate.

Dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate.

Two glyceraldehyde-3-phosphates.

13.

1 point

Reaction 5 of glycolysis involves the _________ of DHAP to glyceraldehyde-3-phosphate.

Phosphorylation

Condensation

Oxidation

Isomerization

14.

1 point

Reaction 5 of glycolysis is catalyzed by:

Phosphofructokinase-1

Aldolase

Triose phosphate isomerase

Hexokinase

15.

1 point

The enzyme of which reaction has a Glu^165 in its active site to transfer a hydrogen from one carbon atom to a neighbouring carbon atom?

Reaction 5: Isomerization of DHAP to glyceraldehyde-3-phosphate

Reaction 2: Isomerization of glucose-6-phosphate to fructose-6-phosphate

Reaction 1: Phosphorylation of glucose

Reaction 4: Cleavage of fructose-1,6-bisphosphate