Chapter 15

The β-adrenergic receptor is a ______ protein

G(alpha) is a GTPase

Match the enzyme with the biological process in which it is involved.
PKB

DAG activates

B? is a second messenger and the product of A?-catalyzed reaction using ATP as the substrate.

The catalytic center of A? is at its _____ domains.

G(alpha) is a ____ protein.

In GPCR activation by epinephrine a very low level of ligand binding to the receptor can stimulate a very strong response (signal amplification) because:

A? is a (an) ____.

epinephrine is a hormone secreted from

In terms of membrane association of trimeric G proteins, which statement is correct?

Which of the following events occur(s) during the epinephrine-stimulated conversion of glycogen to glucose-1-phosphate?

Initiation of mitogenesis by epidermal growth factor and depolarization of the membrane of a skeletal muscle by acetycholine are similar in that each

Which of the following is not a common intracellular second messenger?

Which of the following general statement(s) about a G protein–coupled receptor is (are) true?

Which of the following mechanisms can terminate epinephrine signaling pathway once the concentration of the external signal decreases?

GTPases serve in many signal transduction pathways and the presence of GTP or GDP dictates where the pathway is on or off, respectively. Which of the following statements is true regarding guanine nucleotide exchange factors (GEF) and the role in these signaling pathways?

Which of the following mutations to the Gα protein could render a G protein-coupled receptor signaling pathway constitutively active?

You proposed to your Congresswoman that basic research on GPCR signaling can help drug addicted patients. Which can be scientific evidence to support your argument?

Epinephrine signaling that leads to higher level of blood glucose is an example of signal transduction showing

In muscle, glycogen phosphorylase kinase can be activated by nerve stimulation even in the absence of hormonal signals. Nerve stimulation alone results in activation of glycogen phosphorylase kinase as a result

With regard to the process that acetylcholine regulates opening/closing of ion channels, which statement is CORRECT?

A? is the enzyme functioning as the effector of G-protein transduced signals. A? is

In GPCR activation by epinephrine a very low level of ligand binding to the receptor can stimulate a very strong response (signal amplification) because:

Match the enzyme with the biological process in which it is involved.
PI-3-kinase

Which of the following general statement(s) about a G protein–coupled receptor is (are) true?

Match the enzyme with the biological process in which it is involved.
PKC

Which of the following is NOT a consequence of increased cellular levels of cAMP?

Phosphatidylinositol 4,5-bisphosphate (PIP2) is cleaved by phospholipase C into

Calmodulin

Based on its effects on GTPase, the β-adrenergic receptor of epinephrine can be regarded as a

Activated Ga subunit has intrinsic GTPase activity to provide negative feedback to terminate signal transduction.

1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) are cleaved from phosphatidylinositol 4,5-bisphosphate (PIP2) by the enzyme

All of the following are known to be part of a sginal trandsuction cascade EXCEPT

In paracrine signaling, the signaling molecule

glycogen phosphorylase exists in 2 forms in skeletal muscle. The active form, phophorylase a, is generated from phosphorylase b by

The β-adrenergic receptor of epinephrine is

Rhodopsin, b-adrenergic receptors, and muscarinic acetylcholine receptors share which of the following features?

In terms of trimeric G proteins, which statement is correct?

In trimeric G proteins, GTP binds to

Which of the following is a common step in the opening/closing of ion channels by acetylcholine and rhodopsin binding to their receptors?

Which of the following mechanisms can terminate the intracellular signaling pathway once the concentration of the external signal decreases?

Epinephrine reaches the responding cell through ___ mechanisms.

Phosphatidylinositol is preferentially localized at the cytoplasmic leaflet of plasma membrane.

Match the enzyme with the biological process in which it is involved.
PTEN

How could generation of glucose-1-phosphate helps the physiological function of epinephrine as a stress hormone?

Which statement is TRUE when describing the steps from active PKA to production of glucose-1-phosphate?

Match the enzyme with the biological process in which it is involved.
PKA