OKEP 06 Feb'15

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Donepezil is:

a) Phenyl-methyl derivative

b) Oxyfuran derivative

c) Piperidine derivative

d) N-methyl-D-aspartate derivative

The therapeutic effect of donepezil is due to

a) enhancing GABAeric function

b) enhancing cholinergic function

c) Alters the course of the underlying dementing process.

d) All of the above

CIBIC is:

a) Clinical Global Interview of Change

b) Clinician’s Impression of Change

c) Clinical Global Impression of Change

d) Clinician’s Interview-Based Impression of Change

Absorption of donepezil is linear over the dose range:

a) 23 mg given two daily.

b) 20-30 mg above

c) 1-10 mg given once daily.

d) Both a & c

Elimination half life of donepezil is

a) 70 hours

b) 36 hours

c) 24 hours

d) 48 hours

Donepezil is approximately 96% bound to human plasma proteins, the highest binding constituent to donepezil is?

a) Alpha1 - acid glycoprotein

b) Albumins

c) Globulin

d) Hemoglobin

10.

Concurrent administration of donepezil with _____ would alter the pharmacokinetic parameter of donepezil?

a) Ketoconazole

b) Warfarin

c) Theophylline

d) digoxin

e) None of the above

11.

The side effects seen with donepezil therapy include?

a) Nausea, Vomiting, Diarrhea & Anorexia

b) Insomnia, Dizziness, Depression , Abnormal Dreams & Somnolence

c) Muscle Cramps Headache, Pain, various locations, Accident & Fatigue

d) All of the above

12.

Which of the following scale should be used to judge Cognitive change out come for the trials of donepezil in mild to moderate Alzheimer’s disease?

a) NPI

b) PDS

c) CDR-SB

d) MMSE

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