OKEP 07 March 2015

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Acinetobacter baumanii is gram negative bacilli and displays mechanism of resistance to all existing class of antibiotics.

True

False

Which of the resistance mechanism may lead quinolone, aminoglycoside or tigecycline to be ineffective against acinetobacter species?

a) Antimicorbials inactivating enzymes

b) Reduced access to bacterial target

c) Mutation that change target or cellular function

What is the MIC90 of Kiviza as determined by agar dilution for 115 A.baumannii strains?

a) 2 mg/L

b) 32 mg/L

c) 16 mg/L

Kiviza cannot be given in combination with carbapenem antibiotic.

True

False

According to the study, X.Corbella et al, the activity of sulbactam alone was different to the activity of that of observed ampicillin/sulbactam combination in suscepitibility testing.

True

False

Clinical study of Amoxicillin-sulbactam against A.baumanni shows optimal dose of kiviza should be_____________gm infused over_______________ with______hour interval through human ex-vivo model.

a) 2gm, 15min, 3 hour

b) 2gm,30min, 6 hour

c) 1gm,30min, 6hour

What is the dosage of Kiviza when it is given in combination with suitable antibiotics?

a) 6-8gm 3-4 divided doses

b) 500mg-1000mg every 6-8 hour

c) 1000mg-2000mg every 6-8 hour

10.

Can Kiviza be given to renal patients as monotherapy?

Yes

11.

Kiviza shows_______________ activity against A.baumanii infection.

a) Bacteriostatic

b) Bacteriocidal

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