Week 15: Northam part 2

1.

1 point

Indirect DNA damage from radiation is caused by:

ejection of electrons from an atom

ionisation of water molecules creating free radicals

abnormal cross-linkages

direct chromosomal atom damage

2.

1 point

Cells most sensitive to radiation therapy are:

Erythrocytes

Neurons

Differentiated cells

Labile cells

3.

1 point

Which of the following is Correct?

Lymphoblasts are characterised by having a large open nucleus and little to no visible cytoplasm

Acute lymphoblastic leukaemia is indicated by the presence of myeloblasts in the smear

Bone marrow aspiration is the same as bone marrow biopsy

Red blood cell size normally varies between cells

4.

1 point

Which is not a concern in regards to complementary and herbal therapies and medicines?

Toxic effects of biologically active substances in homeopathic medications

Proving some efficacy and integrating into the mainstream health system

Contamination with heavy metals, more specifically contamination with gems

Lack of regulation

5.

1 point

Who am I? I inhibit the cell cycle at ONLY G2 and am responsive to cancers that are response to hormones. I block oestrogen receptors.

Tamoxifen (SERM)

Methotrexate

Cytotoxic Antibiotics

Anastrazole (aromatase inhibitor)

6.

1 point

Which class of drug am I? I inhibit the cell cycle at ONLY M-phase. I bind to microtubules preventing their formation and polymerisation.

Cytotoxic Antibiotics (aka Anthracyclines)

Tubulin Binding Drugs

Hormone Antagonists

Alkylating Drugs

7.

1 point

Who am I? I am made from a natural product (extracted from a plant genus). I am used to treat gout and have a narrow therapeutic index. When toxicity occurs as an adverse effect i prevent the formation of the mitotic spindle and microtubule polymerisation. Clue: There was an episode about me on the T.V series House. M.D

Methotrexate

Colchicine

Probenecid

Allopurinol

Indomethacin

8.

1 point

Which of those statement(s) are true about the sequence of events following Warfarin consumption:

a Warfarin ultimately inhibit factors 12 and 11 therefore inhibit clotting

b Warfarin inhibits expoxide oxidase which stops the conversion of non-active vitamin K to vitamin K

c Warfarin ultimately inhibit factors 2,7,9, and 10 therefore inhibit clotting

Both b and c is true.

9.

1 point

What is involved in primary haemostasis?

a Vasodilation of vessels and platelet plug formation

b Converting fibrinogen to fibrin

c Vasoconstriction of vessels and platelet plug formation

Both b and c

10.

1 point

What is the function of vitamin K in clotting?

a It adds a carboxyl group to factors 2, 7, 9, 10 so that calcium can bind to those factors

b It adds a hydroxyl group to factors 2, 7, 9, 10 so that calcium can bind to those factors

c It removes a carboxyl group from factors 2, 7, 9, 10 so that calcium can bind to those factors

d It removes a hydroxyl group from factors 2, 7, 9, 10 so that calcium can bind to those factors

Both a and d

11.

1 point

Meiosis is called reduction division. When does the reduction in chromosome number occur?

anaphase I

anaphase II

both metaphase I and metaphase II

interphase

12.

1 point

The P53 protein normally promotes:

apoptosis.

cell division.

DNA repair.

tumour formation.

13.

1 point

The P53 gene is especially prone to:

point mutation.

chromosomal rearrangement.

loss

none of the above.

14.

1 point

An oncogene transcribed and translated with another gene produces a:

fusion cell.

fusion protein.

cancer protein.

transcribed protein.

15.

1 point

The term cancer means:

out of control.

crab.

lobster.

cell division.

16.

1 point

The role of cyclins in the cell cycle:

are expressed at constant levels throughout the cycle

bind to CDK to begin phosphorylation or proteins

inhibit cellular proliferation

assists with DNA replication

17.

1 point

________ is an agent that causes cancer and __________ is an agent that causes mutation to DNA.

MED100, Ninja Turtles

Josh, Alex

cake, a donut

a carcinogen, a mutagen

18.

1 point

Cancer is caused by:

uncontrolled mitosis

uncontrolled meiosis

rupturing of cells

loss of immunity of the cells

19.

1 point

Cancer cells can easily be destroyed by radiation due to:

fast mutation

lack of mutation

lack of oxygen

rapid cell division

20.

1 point

Noncancerous tumours are called:

Oncogenes

Metastisis

Benign

Malignant