OKEP 26 Jun'15

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Epileptic encephalopathy associated with varying degrees of developmental delay is?

a) Status epilepticus

b) Lennox–Gastaut syndrome

c) Both

d) None

Decreased sedative incidence of Clobazam is due to?

a) binding to three different receptors: D2, 5HT1A, 5HT2A

b) Clobazam binds to the D2 receptor with the same affinity than dopamine, but has a lower intrinsic efficacy, so the response it triggers is higher than dopamine.

c) Structural difference than conventional 1 -4 benzidiazepine.

d) All true

Seizures associated with LGS are?

a) Tonic Seizures.

b) Atypical absence Seizures.

c) Drop seizures.

d) All of the above

Clobazam is?

a) Partial D2 agonist

b) Partial agonist to GABAA

c) Complete agonist to GABAA

d) Complete agonist D2 receptor

The half-life Clobazam in adults with epilepsy is?

a) 12 hrs

b) 24 hrs

c) 16 hrs

d) None

Dosing of Clobazam is based on?

a) Body surface area (BSA)

b) Body weight

c) Renal Function

d) All of the above

10.

A patient named Kshitij at the age of 10 yrs has been diagnosed with LSG weighing 35 kg. The doctor prescribed Lobachek to control seizers. What will be the starting dose of Lobachek?

a) Lobachek 5mg

b) Lobachek 10 mg

c) Lobachek 15 mg

d) Any of the above depending on choice of physician

11.

The market value of clobazam is?

a) 115 INR Crs

b) 100 INR Crs

c) 125 INR Crs

d) 140 INR Crs

12.

Which of the following is not a competitor to Lobachek?

a) FRISIUM

b) AEDON

c) CLORSTA

d) CLOGABA

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