OKEP August 15

1.

Name:

2.

Territory:

3.

Pregabalin is structurally related to?

a) Tricyclic Anti Depressant

b) γ-aminobutyric acid

c) voltage-gated calcium channels

d) None

4.

Which of the following has longer half life in the given range of therapeutic dose?

a) Pregabalin

b) Gabapentin

c) Both have almost same half life

5.

Which of the following show linear pharmacokinetics?

a) Pregabalin

b) Gabapentin

c) Both

d) None

6.

Which of the following has almost zero percent plasma protein binding?

a) Serotonin

b) Pregabalin

c) Gabapentin

d) Sertraline

7.

Which of the following has higher α2δ1 subunit binding for voltage-gated calcium channels?

a) Serotonin

b) Gabapentin

c) Pregabalin

d) Sertraline

8.

Pregabalin is used for the treatment of?

a) Diabetic peripheral neuropathy

b) Postherpetic neuralgia

c) Adjunctive therapy for adult patients with partial onset seizures

d) Fibromyalgia

e) All of above

9.

Initiating treatment with Pbren, it is important to start with dose?

a) 50 mg

b) 75 mg

c) 100 mg

d) 150 mg

10.

Which of the following statement is not correct about Pregabalin (PGB)?

a) PGB was approved for NeP management in 2004 within the USA and Europe

b) Interactions between gabapentinoids and other medications are very rare because gabapentinoids do not demonstrate any substantial binding to plasma proteins

c) PGB’s pharmacokinetics are not affected by genetic polymorphisms of cytochrome P450 isoenzymes

d) When discontinuation of PGB is needed, it is best to perform fast weaning over several days before stoppage

e) All are correct

11.

Antinociceptive and antiseizure property of Pregabalin is due to

a) α2δ1 subunit binding of sodium channel

b) α2δ1 subunit binding of calcium channel

c) α2λ1 subunit binding of sodium channel

d) α2λ1 subunit binding of calcium channel