OKEP Sep'15

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In the given study, mucosal healing correlates directly with the proportion of the 24-h period with intragastric pH___.

a) >4

b) <4

c) =4

Esomeprazole differs from Omeprazole by ____.

a) Lower first-pass hepatic metabolism

b) Slower plasma clearance

c) Higher plasma concentrations

d) All of the above

Esomeprazole 40 mg achieved control of intragastric acidity for ___, compared with Omeprazole 20 mg for ___ of the 24-h period.

a) 40% and 70%

b) 77% and 40%

c) 44% and 70%

d) 70% and 44%

Esomeprazole 40mg, Esomeprazole 20 mg and Omeprazole 20 mg maintained intragastric pH for (mean) ___ , ___ and ___ hours respectively.

a) 10.5h, 12.7h and 16.8h

b) 16.8h, 12.7h and 10.5h

___ patients completed the study.

a) 38

b) 37

c) 36

d) 35

Exclusion criteria of the study are___ .

a) gastrointestinal bleeding

b) history of esophago-gastric surgery

c) female patients

d) (a) and (b)

e) (a) and (c)

10.

Intragastric pH > 4 was maintained for more than 12 h in _____ of patients receiving esomeprazole 40 mg, esomeprazole 20 mg and omeprazole 20 mg respectively.

a) 44%, 54% and 92%

b) 92%, 54% and 44%

c) 54%, 44% and 92%

11.

____ is a racemic mixture of the R- and S-isomers.

a) Omeprazole

b) Esomeprazole

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