Pharmacology Exam 3

1.

1 point

Meloxicam is...

COX-1 and COX-2 inhibitor, but more selective to COX-2

COX-1 inhibitor only

COX-1 and COX-2 inhibitor, but more selective to COX-1

COX-2 inhibitor only

2.

1 point

If a patient were in critical care, which type of -cillin antibiotic would they receive?

Amoxicillin combined with Ticarcillin

Piperacillin

Amoxicillin-clavulanate (Augmentin)

Oxacilli

3.

1 point

When taking Celecoxib (Celebrex), renal patients should...

take a usual dose

decrease the usual dose by 50%

not take the medication at all

take every other day

4.

1 point

bactericidal agents...

kill bacteria

inhibit bacterial growth and repication

inhibit then kill bacteria

fight against cancer cells

5.

1 point

This is not a labeled adverse effect of ibuprofen

dizziness

dry mouth

heart burn

increased BUN and creatinine

6.

1 point

Sharon is experiencing acute gouty symptoms. When should she take Colchicine (Colcrys)?

1 dose at onset and another dose the next day at the same time

1 dose at onset and another dose 1 hour later

1 dose 30 minutes after onset and another dose the next day at the same time

1 dose 30 minutes after onset and another dose 4 hours later

7.

1 point

Colchicine (Colcrys) decreases the absorption of what vitamin(s)?

B12

A and B

B6

K

8.

1 point

When taking Celecoxib (Celebrex), hepatic patients should...

take every other day

decrease the usual dose by 50%

not take the medication at all

take a usual dose

9.

1 point

Thomas is a 68 year old male and does not have any significant health problems other than occasional, mild bursitis in his left elbow. Indometican (Indocin) is safe for him to take to alleviate his symptoms.

True

False

10.

1 point

What type of drugs should not be taken concurrently with Colchicine (Colcrys)?

Cyclosporine and tetracycline

Penicillin and tetracycline

Cyclosporine and Ranolazine

Penicillin and cephalosporin

11.

1 point

Lucy is allergic to aspirin. Is another drug, such as Meloxicam, a good alternative to help relieve her RA pain?

Yes. Her allergy to aspirin is unrelated to any reaction she might have with Meloxicam.

No. Meloxicam is contraindicated for patients with an allergy to aspirin.

12.

1 point

Which one of these is not an anti inflammatory response of corticosteroids?

decrease leakage

decrease accumulation of platelets

decrease production of prostaglandins

decrease capillary permeability

13.

1 point

Randy is sitting in his recliner, watching TV with his wife, and notices that his right great toe is inflamed. The inflammation is accompanied by a sharp pain and it also appears to be red in color. Randy has never experienced something like this before so he calls to make an appointment with his doctor the next day. Which of the following drugs might Randy's doctor advise that he take to help reduce the pain until he is able to attend his appointment the next day?

acetaminophen

ibuprofen

aspirin

none of the above

14.

1 point

When do you draw trough levels?

Every hour

1.5-2 hours pre infusion

1.5-2 hours post infusion

30 minutes prior to the next dose

15.

1 point

The following are symptoms of salicylism

dizziness, tinnitus, difficulty hearing, mental confusion

dizziness and tinnitus only

dizziness, tinnitus, difficulty breathing, wheezing

dizziness, tinnitus, difficulty hearing, shortness of breath

16.

1 point

Indomethican (Indocin) inhibits..

Both, but mainly COX-1

Only COX-1

Both, but mainly COX-2

Only COX-2

17.

1 point

Bobby is a 45 year old patient with renal impairment. He has been prescribed Allopurinol (Zyloprim) and his doctor has based his prescription dose on..

his age

his creatinine clearance

his BUN levels

his gender

18.

1 point

Aspirin can be used for...

rheumatoid arthritis, osteoarthritis, and spondyloarthropathies

rheumatoid arthritis and osteoarthritis

osteoarthritis only

rheumatoid arthritis only

19.

1 point

What does Ampicillin (Principen) primarily act against?

Gram + and Gram - equally

Gram +

Gram -

20.

1 point

If Alan takes Colchicine (Colcrys), what are the most common side effects he should expect to have?

CNS (drowsy, headache, vertigo)

GI (nausea, vomiting, diarrhea, abdominal pain, dyspepsia)

Anaphylaxis

Cardio (chest pain, palpitations)

21.

1 point

Sean's doctor recommended that he take 250 mg Ibuprofen as needed for his mild rheumatoid arthritis. Which of the following instructions might Sean's doctor give him?

take 1 hour before meals or 2 hours after meals

decrease daily water intake

take with food and/or liquid

do not take with food, but drink 8 oz of water

22.

1 point

What happens when histamine binds to H2 receptors?

increased respiratory rate, tachycardia, dilated pupils

increased secretion of gastric acid, tachycardia, inhibition of lymphocyte function

diaphoresis, bronchoconstriction, chills

palpitations, upset stomach, shaking/tremors

23.

1 point

How many doses of antibiotics does it take to get to a "steady state"?

3

2

6

4

24.

1 point

Which one of these is not a super infection?

C. difficile infection

Vaginal yeast infection

Candidiasis

Strep throat

25.

1 point

Inhibition in COX-1 activity in platelets may be more responsible for GI bleeding than inhibition of COX-1 activity in gastric mucosa

True

False

26.

1 point

It is sometimes recommended that children at risk for seizures who are receiving the Tdap immunization also receive aspirin

True

False

27.

1 point

The benefit of COX-2 inhibitors vs COX-1inhibitors

they are specifically protective of the kidneys and stomach

they have fewer adverse effects than COX-1 inhibitors

they work on all body tissues

none of the above

28.

1 point

Cheryl is a renal patient and has been prescribed a penicillin drug. All penicillin based drugs are safe for her to take except for

Amoxicillin-clavulonate (Augmentin)

Dicloxacillin

Piperacillin (Pipracil)

Ticarcillin-clavulanate (Timentin)

29.

1 point

Martin, a 52 year old male with hepatic impairment, has chronic osteoarthritis and does not like the current medication that he is on. His wife, Nancy, takes Meloxicam for her rheumatoid arthritis and she tells Martin that it is great in relieving her pain. Is Meloxicam safe for Martin to take?

Yes, there are no contraindications or recommended dose changes for those with hepatic impairment

No, this drug is contraindicated for those with hepatic impairment

No, this drug should only be taken for rheumatoid arthritis

Yes, but he should talk to his doctor first about cutting the usual dose in half because of his hepatic impairment

30.

1 point

Aspirin does not cross the placenta or enter the breast milk

True

False

31.

1 point

What is the BBW for ibuprofen?

contraindicated for those under 18 years old

contraindicated for the treatment of perioperative pain after CABG

risk of hepatotoxicity

do not give to patient's with a history of seizures

32.

1 point

***This is not a question. Just a reminder of what a BETA-LACTAMASE is***

enzyme produced by some bacteria that attacks the beta-lactam ring, rendering the drug ineffective and leading to a resistance to beta-lactam antibiotics

33.

1 point

Sarah takes Meloxicam as needed to help with her mild RA. She believes that she would be able to function well without the medication, however, it does help relieve some pain and inflammation. Sarah is now 2 weeks away from entering her 3rd week of pregnancy. Should she continue taking the drug at that time?

Yes. Meloxicam is considered to be in pregnancy category A.

No. Meloxicam is considered to be in pregnancy category D during the 3rd trimester.

34.

1 point

What is the antidote for aspirin overdose?

acetylcystine

acetylase

acetaminophen

acetylcorticoid

35.

1 point

What is the BBW for Prednisone (Apo-Prednisone, Deltasone)?

do not take if you are over the age of 65

do not take if you just transferred from systemically active corticosteroids to a flunisolide inhaler

do not take if you are pregnant due to the risk of fetal malformation or death

do not take if you are currently taking vitamin B12 supplements

36.

1 point

What is the Black Box Warning for Aspirin?

Risk for lung collapse in adults over 55 years of age

Cardiac and vascular risks

do not give to children because of association with Reye's syndrome (encephalopathy, hepatic damage)

Do not take if you have been diagnosed with Crohn's disease

37.

1 point

What may result from taking IV Penicillin G Benzathine (select all that apply)

Cardiopulmonary death

Fatal bleeding

Seizure

Death

All of the above

38.

1 point

Emily is 32 years old and is about to go into labor with her 3rd child. She is at the hospital and is experiencing severe pain, which she believes is inflammation. Emily has received a Ketorolac injection in the past when she was experiencing severe idiopathic knee pain. She asks her nurse if she can receive this medication at this time but her nurse explains that she cannot give it to her because:

Ketorolac is contraindicated for patients under 50 years old

Ketorolac is a discontinued drug

Ketorolac is contraindicated in patients at risk for excessive bleeding

Ketorolac is only used for joint related pain and inflammation

39.

1 point

When is it acceptable for children to take Allopurinol (Zyloprim)?

When they are age 5 or older

When they are undergoing cancer/chemotherapy treatment

In the case of an allergic reaction to Colchicine (Colcrys)

Children should never take Allopurinol under any circumstances

40.

1 point

Amanda is to follow a low purine diet while taking Colchicine (Colcrys) for her gouty symptoms. Which types of foods should she avoid?

dairy products and other foods containing calcium

beer, alcohol, anchovies, and asparagus

acidic foods (grapefruit juice, orange juice, tomatoes)

foods that are high in fiber (leafy greens, fruits)

41.

1 point

Renal function should be monitored when taking salicylates, non narcotic analgesic antipyretics, and NSAIDs

True

False

42.

1 point

Ampicillin is a broad spectrum antibiotic

True

False

43.

1 point

Un unlabeled use for Celecoxib (Celebrex) is

use in adjunctive therapy for schizophrenia

use for brain tumor prevention

use for insomnia

use for antihypertensive effect

44.

1 point

This is therapy based on an informed estimate of the most likely pathogen(s) given the patient's signs and symptoms and the site of infection, as well as knowledge of communicable diseases currently infecting others in the community

therapeutic therapy

scientific method

patient centered therapy

empiric therapy

45.

1 point

This/these drugs increase the risk of hepatotoxicity and delay absorption in patients taking aspirin

carbamazapine, phenytoin, rifampin

phenytoin and rifampin

cabamazapine and phenytoin

rifampin only

46.

1 point

Which antibiotic would most likely cause a rash if taken in conjunction with Allopurinol (Zylopri)?

Penicillin

Tetracycline

Cephalosporin

Carbapenem

47.

1 point

Susan is 53 years old and has a history of diabetes and hypertension. She does not need to use caution when taking ibuprofen for her occasional joint pain.

True

False

48.

1 point

Allison suffers from primary dysmennorhea. Which one of these drugs is best for her to take?

Aspirin

Celecoxib (Celebrex)

Ibuprofen

Colchicine (Colcrys)

49.

1 point

What is the MOA of aspirin and NSAIDs?

inhibit the synthesis of DNA

block the protein synthesis of prostaglandins

bind to the cell wall membrane, leading to cell death

none of the above

50.

1 point

When do you draw peak levels?

Every hour

30 minutes prior to the next dose

1.5-2 hours pre infusion

1.5-2 hours post infusion