OKEP 10 JUNE'16

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The improvement in pain relief was not accompanied by a dose-related incidence of adverse events.

As per the article, the prevalence of diabetic neuropathy is as high as 50% in patients who have had diabetes for 25 years

Painful diabetic peripheral neuropathy (DPN) occurs in up to 26% of all people with diabetes.

As per article, treatment duration ranged from __ to __ weeks.

As per article, pooled analysis showed that pregabalin significantly induced pain and pain related sleep interference associated with DPN.

Only the ___ mg/day dosage showed efficacy when administered BID.

Pain and sleep interference reductions associated with pregabalin appear to be Kaplan-Meier analysis revealed that the median time to onset of a sustained 1-point improvement was __ days in patients treated with pregabalin at 300 mg/day & __ days in patients receiving placebo.

Treatment with pregabalin across its effective dosing range is associated with significant, dose-related improvement in pain in patients with DPN.

Nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at beta-adrenergic receptors.