OKEP 15 April'16

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Fibromyalgia is an acute musculoskeletal pain disorder.

People with Fibromyalgia have substantial functional impairment and additional disabling symptoms such as sleep disturbance and fatigue

Flexible-dose pregabalin __ was added for 3-month treatment cycles

Each followed by __ pregabalin “drug holiday” that lasted until a relapse occurred.

Analysis period for the treatment with pregabalin as per article was 15 weeks.

Pain intensity was measured using the visual analogue scale of the Short-Form McGill Pain Questionnaire uncompleted at baseline.

Somnolence and dizziness were the most common adverse events with the treatment as per the article.

Pregabalin is an aplha2-delta ligand with analgesic activity that is mediated by its ability to bind with ___ affinity to the alpha2-delta subunit of voltage-gated calcium channels in central nervous system (CNS) tissues.

By binding to the alpha2-Delta subunit of voltage-gated calcium channels in the CNS and modulating calcium channel function pregabalin has been shown to reduce neurotransmitter release from ___, hyper excited nerve terminals.