OKEP 29 April'16

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1.
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4.
Voltage-gated calcium channels activity isn’t modulated by Pregabalin’s α2δ ligand for its action.








5.
The article study reports findings of adjunctive pregabalin for the treatment of preoperative pain.










6.
As per the article, in __, pregabalin is indicated for peripheral and central neuropathic pain, epilepsy, and generalized anxiety disorder.







7.
Patients underwent two of three categories of surgical procedures: elective inguinal hernia repair (post-IHR); elective total knee arthroplasty (post-TKA); or total abdominal hysterectomy (posthysterectomy)






8.
The __ endpoint in each trial, mean worst pain over the past 24 hours, was assessed 24 hours post-IHR and posthysterectomy, and 48 hours post-TKA.








9.
Patients rated their pain on a scale from zero to ten, with __ scores indicating __ pain severity.







10.
There were no statistically significant differences between the pregabalin and placebo groups with respect to the secondary endpoint in any of the three trials.







11.
In the US, pregabalin is indicated as an adjunctive therapy for adult patients with partial onset seizures.









12.
M.R.P. of Pbren 50 mg & Pbren 75 mg is ___ respectively.