Toxicology3

1.

1 point

Which of the following teratogens is a bacterial infection:

Rubella

Hepatitis B

Toxoplasmosis

Syphilis

2.

1 point

Phosgene is the metabolite of:

Ethanol

Paracetamol

Carbon tetrachloride

Aflatoxin

3.

1 point

The antidote in warfarin toxicity is:

Methotrexate

Cyclophospamide

Erythromycin

Vitamin K

Vitamin C

None of the above

4.

1 point

Which of the following is a rodenticide:

Warfarin

Bromodiolone

Strychnine

Difenacoum

None of the above

All of the above

5.

1 point

The minimum dose that produces an effect is known as LD50

True

False

6.

1 point

Phase I reaction involves hydrolysis, oxidation, sulfation and methylation:

True

False

7.

1 point

All of the following are stimulants except:

Mexedrone

Naphyrone

Phenazepam

5-iodo-2-aminoindan

8.

1 point

Mephedrone is a parasympathomimetic substance:

True

False

9.

1 point

The mechanism of absorption in the glomerulus is active transport:

True

False

10.

1 point

Atropa Belladonna is a plant that works on the peripheral nervous system and:

Contains atropine alkaloid which induces temporary bradycardia

Contains atropine alkaloid which induces instant tachycardia

Contains strychnine which produces nausea

Contains atropine which produces hypertension, nausea and vomiting

11.

1 point

When a high dose of benzodiazepine is taken with alcohol it causes a drug-drug interaction; being respiratory depression and death. The relationship between benzodiazepines and alcohol is known as:

Additive

Potentiation

Agonist

Antagonist

Synergism

12.

1 point

Amphetamine is a parasympathomimetic substance abused by atheletes

True

False

13.

1 point

The impulse in a neuron moves from an axon to a dendrite:

True

False

14.

1 point

Which of the following statements is true:

The cell membrane consists of a phospholipid bilayer with a non-polar molecule in the outer core and allows the passage of lipid soluble substances

The inhalation route is the quickest route of absorption of toxic substances

Passive diffusion occurs against the concentration gradient in a membrane

Weak acids such as aspirin get absorbed from the stomach

None of the above

15.

1 point

The peripheral nervous system is composed of the brain only:

True

False

16.

1 point

Cadmium (Cd) affects all of the following organs except:

Bones

Lungs

Kidneys

Heart

17.

1 point

The blood brain barrier is highly permeable to water soluble compounds:

True

False

18.

1 point

Dopamine, serotonin and loratadine are all examples of neurotransmitters:

True

False

19.

1 point

Which of the following describe absorption of toxic compounds through the skin:

Blood flow

Lipid solubility

pH

Molecular weight

None of the above

20.

1 point

Biotransformation mainly involves the conversion of a drug to a lipid soluble compound:

True

False

21.

1 point

Lead (Pb) toxicity can only involve acute exposure:

True

False

22.

1 point

Only intentional overdoses are counted as drug induced toxicity:

True

False

23.

1 point

The slowest route of drug absorption is:

The intravenous

The intramuscular

The oral

The subcutaneous

24.

1 point

Domepezil is a parasympathomimetic chemical with no hepatotoxicity. It has several side effects, such as salivation, lacrimation, urination etc. Do you think it is safe to use it in bronchial asthma:

Yes

No

25.

1 point

LC-MS is a hyphenated technique which can separate drugs and detect their masses:

True

False

26.

1 point

DDT insecticide is hydrophilic and thus it deposits in tissues:

True

False

27.

1 point

Sahwann cells are present in the dendrites:

True

False

28.

1 point

Which of the following contribute to the tissue distribution of a drug given orally:

Plasma pH

Plasma protein binding

Lipid solubility

Hepatic first pass metabolism

Tissue blood flow

29.

1 point

Which of the following is a cardiac glycoside:

Dopamine

Digoxin

Castor oil

Malathion

30.

1 point

Mutagenicity determines:

Pulmonary irritation

Skin irritation

Gastrointestinal damage

Genetic damage

Carcinogenesis

31.

1 point

Neurotoxicity often results from chemicals; yet it can be caused by certain infections:

True

False

32.

1 point

Encephalopathy underlies:

Lethargy

Vomiting

Loss of appetite

Dizziness

All of the above

None of the above

33.

1 point

Glucose is essential for energy production:

True

False

34.

1 point

Which of the following cause near death experience:

Mephedrone

Lead

Methoxetamine

Chlordane

Parathione

35.

1 point

Phosgene is the metabolite of carbon tetrachloride:

True

False

36.

1 point

Glutathione detoxifies the metabolite of:

Carbon tetrachloride

Ethanol

Paracetamol

Aflatoxin

37.

1 point

Which of the following is incorrect:

Hypertension opens blood-brain-barrier (BBB)

Infection opens the BBB

The BBB is permeable to highly water soluble compounds

None of the above

38.

1 point

Which of the following is not true about first pass metabolism:

It can occur with any route of drug administration

It is facilitated by liver secretions, thus, can only metabolise basic toxins

Transferase enzymes are involved in first pass metabolism

It differs depending on the pH of the toxin

All of the above

None of the above

39.

1 point

The sympathetic nervous system is responsible for:

Pupil constriction

Salivary secretion

Bronchodilation

Stimulation of intestinal motility

None of the above