OKEP 10th June'16

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S-Adenosylmethionine (SAMe) has rapidly moved from being a _____ donor to a key _______ that regulates hepatocyte growth, death, and differentiation.

a. Ethyl, metabolite

b. Methyl, metabolite

c. Quaternary, metabolite

Electron, metabolite

Increased hepatic SAMe biosynthesis is a consequence of all forms of chronic liver injury

True

False

GNMT stands for __________, which on mutation in patient causes impaired SAMe metabolism that causes liver damage.

a. Gluco N-methyl transferase

b. Glycine N mono transferase

c. Glycine N-methyltransferase

d. none of the above

Which of the following is the mechanisms have been proposed for SAMe’s protective action?

a. Increased GSH levels

b. A change in DNA methylation

c. improved membrane fluidity

d. Decreased tumor necrosis factor alpha expression e. All

e. All of the above

SAMe protects normal hepatocytes, it decreases apoptosis in liver cancer cells.

True

False

Hepatectomy is the_______ of liver.

a. surgical resection of the liver

b. Replacement of liver

c. Renewal of liver

d. None of the above

10.

In the article II the patients were divided into ______ groups.

a. Post-treatment(n-23), post treatment(n-30), control group(n-25)

b. Pretreatment(n-26), Post treatment(n-25), Control group(n-30)

c. post treatment(n-30), control group(n-25)

d. pre-treatment(n-30), control group(n-25)

11.

Preoperative administration of SAMe significantly increases the plasma levels of alanine transaminase (ALT), aspartate transferase (AST), total bilirubin (TBIL) and direct bilirubin (DBIL) as compared to the other two groups

True

False

12.

Which of the following is not mentioned indication in Cirrosam LBL?

a. Alcoholic Liver Disease

b. Liver Cirrhosis

c. Hepatitis

d. Hepatocellular carcinoma

e. Pancreatitis

13.

Preoperative administration of SAMe is useful and safe for reducing the HIRI in partial hepatectomy.

True

False

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