OKEP 02 September 2016

Is this your test? Login to manage it. If not, you can build a quiz just like it.

This is a non-interactive preview of the quiz content.

Full Name:

Territory:

Email Id:

Donepezil is?

d) N-methyl-D-aspartate derivative

a) Phenyl-methyl derivative

b) Oxyfuran derivative

c) Piperidine derivative

d) N-methyl-D-aspartate derivative

The therapeutic effect of donepezil is due to?

a) enhancing GABAeric function

b) enhancing cholinergic function

c) Alters the course of the underlying dementing process.

d) All of the above

Which of the following is not true?

a) In AD there is neuronal cell loss, deposition of amyloid plaques, neurofibrillary tangles and secondary inflammation

b) Donepezil is metabolized by the cytochrome P450 isoenzymes 2D6 and 3A4 in the liver

c) The mean volume of distribution of Donepezil is 9-11 L/kg and the plasma protein binding is low (45%)

d) Patients with MMSE score 10-19 in this study suffer with moderate AD

Absorption of memantine is linear over the dose range?

a) 28 mg given twice daily.

b) 20-30 mg above

c) 5-10 mg given once daily.

Elimination half life of memantine is?

a) 70 hours

b) 36 hours

c) 24 hours

d) 48 hours

Memantine is postulated to exert its therapeutic effect through?

a) Agonistic activity at GPCR receptor

b) Antagonistic activity at GPCR receptor

c) Agonistic activity at NMDA receptor

d) Antagonistic activity at NMDA receptor

10.

Which of the following scale should be used to judge Cognitive change out come for the trials of donepezil in mild to moderate Alzheimer’s disease?

a) NPI

b) PDS

c) CDR-SB

d) MMSE

11.

The total Indian market value for Memantine and Donepezil Combination 10/5 MG is (INR Crs)?

a) 27.0

b) 18.4

c) 8.1

d) 14.6

12.

The market value of DONAMEM is?

a) 7.7

b) 10.8

c) 4.2

d) 14.6

Home Features Pricing FAQs Legal Sample Tests Build a Test Login/Sign Up