OKEP 16'Sep 16

1.

Full Name:

2.

Territory:

3.

Email Id:

4.

As per Cholinergic hypothesis of AD states which of the following statement is correct?

a) Degeneration of cholinergic neurons in the ventral forebrain

b) The area of brain important for memory are temporal and parietal neocortex and hippocampus

c) Cholinesterase inhibition increase acetyl Choline (Ach) levels at the synapses and pre-synaptic receptors and maintain some function in the cholinergic system

d) All of the above

5.

The therapeutic effect of donepezil is due to?

a) enhancing GABAeric function

b) enhancing cholinergic function

c) Alters the course of the underlying dementing process

d) All of the above

6.

CIBIC is?

a) Clinical Global Interview of Change

b) Clinician’s Impression of Change

c) Clinical Global Impression of Change

d) Clinician’s Interview-Based Impression of Change

7.

Absorption of donepezil is linear over the dose range?

a) 23 mg given two daily

b) 20-30 mg above

c) 1-10 mg given once daily

d) Both a & c

8.

Which of the following is least selective for AChE than for BuChE?

a) Donepezil

b) Galantamine

c) Rivastigmine

d) All with same selectivity

9.

Which of the following statement is not true about donepezil?

a) Donepezil is a mixed competitive and noncompetitive AChE inhibitor that shows a relative selectivity for AChE compared with BuChE

b) Donepezil undergoes an extensive hepatic first pass metabolism therefore 11–17% of drug excreted 5-O-desmethyl donepezil, 6-O-desmethyl donepezil and donepezil-cis-N-oxide in urine

c) It is a piperidine derivative

d) All are true

10.

Concurrent administration of donepezil with _____ would increase donepezil plasma concentrations?

a) Warfarin

b) Theophylline

c) Ketoconazole

d) digoxin

11.

The side effects seen with donepezil therapy include?

a) Nausea, Vomiting, Diarrhea & Anorexia

b) Insomnia, Dizziness, Depression , Abnormal Dreams & Somnolence

c) Muscle Cramps Headache, Pain, various locations, Accident & Fatigue

d) All of the above

12.

Which of the following scale should be used to judge Cognitive change out come for the trials of donepezil in mild to moderate Alzheimer’s disease?

a) NPI

b) PDS

c) CDR-SB

d) MMSE