OKEP 02 Dec 16

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Levetiracetam belongs to:

a) Pyridinium family

b) Thiazides family

c) Amylin analogs family

d) Pyrrolidone family

Levetiracetam was approved by the CDRI in the year _____ as an adjunctive therapy in the treatment of partial-onset seizures in adults with epilepsy?

a) 2000

b) 1999

c) 2005

d) 2012

Three major molecular targets inlcudes ?

a) SV2A protein; inhibition of Ca2+ N-type channels,

b) neuromodulator action on GABA,

c) 5HT, α2-adrenergics, and μ-opioidergic pathways

d) All of the abaove

Total Levetiracetam Market for August 2016 and growth is (INR Crs)?

a) 392.4 & 23.6 %

b) 469.4 & 23.6 %

c) 469.4 & 19.6 %

d) 392.4 & 17.5 %

Which of the following class of drug of Levetiracetam growing at most among the following?

a) TABLET XR

b) SYRUP

c) TABLET ER

d) INJECTION

Total Market (MAT OCT 2016) of LEVERA from Intas is valued of ____ and growing at the rate of ___ (INR Crs)?

a) 88.9 & 23.6 %

b) 109.6 & 23.2 %

c) 137.3 & 19.6 %

d) 163.7 & 17.5 %

10.

Levetiracetam treatment should be initiated _______ dose range for Partial Onset Seizures in patient with Ages 4 To <16 Years?

a) with a daily dose of 1000 mg/day BD

b) 10 mg/kg BID

c) 30 mg/kg BID

d) with a daily dose of 1000 mg/day

11.

Levetiracetam has ability to hyperpolarize membrane potential via

a) K+ channel activation

b) inhibition of Ca2+ entry into the cells

c) both a & b

d) None

12.

The dosing of Levetiracetam varies according to indication. A patient suffering the chronic kidney disease (CKD) with GFR < 30mL/min/1.73 m 2 and suffering with seizures at the age 68 been prescribed for levetiracetam tablet; What will be the dose of drug?

a) 1000mg BD

b) 1000 mg TID.

c) 750 BD

d) 500 mg BD

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