Polymorphism in MHC I & II

1.

1 point

In molecular mimicry, molecules on the surface of bacteria mimics HLA.

True

False

2.

1 point

Molecular mimicry can cause which of the following?

Down regulation of Class I markers on all nucleated cells.

No immune response to the pathogen

Up regulation of both Class I & II markers on APCs.

Down regulation of Class I markers on all APCs

Autoimmune response to all host tissues expressing the HLA marker

3.

1 point

Which of the following is/are Class I gene on the H-2 locus?

H-2A

H-2D

H-2E

H-2K

H-2L

4.

1 point

How many different HLA class I isotypes are there?

4

6

10^13

8

2

5.

1 point

Which of the following is/are associated with Anklosing spondylitis?

E. Coli

Epstein Barr virus

Coxackie Virus

Klebsiella pneumonia

HHV-6

6.

1 point

Which of the following is/are HLA class I markers?

HLA-D

HLA-G

HLD-DO

HLA-A

HLA-DM

7.

1 point

If a father has HLA-A & HLA-C, the mother has HLA-B & HLA-E. Which of the following is a possible Class II marker genotype for their son?

HLA-A, HLA-C

None of the Above

HLA-B, HLA-B

HLA-B, HLA-E

HLA-B, HLA-A

8.

1 point

Which of the following are functions of H-2 MHC molecules?

Markers of self

Tumor suppression

Antigen presentation

Control acceptance or rejection of blood transfusion

Immune response

9.

1 point

Which of the following is/are HLA class II markers?

HLA-DR

HLA-DP

HLA-F

HLA-G

HLA-DE

10.

1 point

MHC:Mouse::____:Human

11.

1 point

How many different HLA class II isotypes are there?

6

8

9

10^13

5

12.

1 point

Which of the following is/are characteristics of I region markers?

They are Class II markers

H-2A and E is expressed on APCs.

They are Class I Markers

They are Constitutive

They are Induced

They are present on all nucleated cells

13.

1 point

Which of the following is/are Class II gene on the H-2 locus?

H-2A

H-2D

H-2E

H-2K

H-2L

14.

1 point

Which of the following is/are caused by molecular mimicry?

Anklosing spondylitis

Multiple Sclerosis

Kawasaki Disease

Rheumatoid Arthritis

Sjogren Syndrome

15.

1 point

Which of the following is FALSE about the Genetic Restriction Theory

Self and parent's tissue are not recognized as foreign

T cell recognition of antigen occurs only when the T cell and APC have the same HLA markers.

There are interactions between the HLA and the TCR

16.

1 point

Class I and II markers that present antigen are also markers of self.

True

False

17.

1 point

Which of the following Describes Ankylosing Spondylitis?

93% of all patients have HLA-DR4

Cause fusion of vertebral disks

Autoimmune response to cells expressing HLA-DR4

Inflammatory Disease of the lower back

Autoimmune response to cells expressing HLA-B27

18.

1 point

All individuals can present antigens in on Class II molecules.

True

False

19.

1 point

Haplotype is the complete set of HLA markers inherited from both mother and father. Genotype is the set of allelic variants present at a given genetic region.

True

False

20.

1 point

Which of the following is/are true about HLA polymorphism?

The polymorphic site is in the Class II is in the ß1 region.

The polymorphic site in the Class II is in the α1& ß1 region.

Everyone have 4 isotypes for each class

Multiple isotypes prevents a single virus from wiping out an entire population.

The polymorphic site in the Class I is in the α1&2 region.